More recently, we discovered that a significant fraction of HSP70 in tumors is localized to mitochondria. We also find that this compound extends the response of melanoma to current therapies like BRAF and MEK inhibitors. Maureen has 5 jobs listed on their profile. Our heritage is the cornerstone for our future and the legacy which supports our pursuit of the highest standards in education, research, and patient care. Graduate Group Affiliations Cell and Molecular Biology; Biochemistry and Molecular Biophysics; Contact information. Her work seeks to understand the impact of these genetic variants of p53 on cancer risk and the efficacy of cancer therapy. Murphy also studies the cancer-survival protein HSP70. The Murphy lab uses a series of novel HSP70 inhibitors they have created for the therapy of human tumors, with focus on colorectal cancer and melanoma. Office: 215-495-6870 Lab: 215-495-6869. Penn has a proud tradition of translating knowledge into social-minded action that dates back to our founder, Benjamin Franklin.
Specifically, I am interested in the role that nrp2a, nrp2b, and sema3fa play in the differential axon targeting of OMP and TRPC2 expressing olfactory sensory neurons.I am currently working on determining the function of a previously uncharacterized circadian oscillating long noncoding RNA (lncRNA) that may modulate the degradation of an important chromatin modifying complex.
Work in the Murphy lab also aims to identify novel cancer therapies that are more effective on tumors that contain genetic variants of p53 that exist in African Americans and Ashkenazi Jewish populations, in order to improve personalized medicine.p53 is the most important gene in human cancer. Her laboratory focuses on genetic variants of p53 that exist in populations of African-descent (P47S and Y107H) and Ashkenazi Jewish (G334R).
Additionally, I will be examining the mechanism of action of DVG-derived oligonucleotides as vaccine adjuvants to understand how these adjuvants are able to induce type-I immune responses. The lab studies genetic variants of the p53 gene that exist in different ethnic groups.
Murphy is an adjunct professor at Drexel University College of Medicine and The Perelman School of Medicine at the University of Pennsylvania.HSP70 is a cancer-critical chaperone protein that allows tumor cells to survive under conditions of stress and aneuploidy by preventing proteotoxic stress. I am particularly interested in how the metabolic enzyme ACSS2 is recruited to the chromatin and how this recruitment impacts learning and memory in mice.I will be studying HIV integrase.
She joined The Wistar Institute in 2011.
We’re seeking technologies that have clear product potential in life science and healthcare markets.Final Presentations to Selection TeamFinalist Projects Selected (10-15)Maureen Murphy, Ph.D. at The Wistar Institute and QED Awardee
She is also an adjunct professor at Drexel University College of Medicine and The University of Pennsylvania Raymond and Ruth Perelman School of Medicine. I am using proteomics, live imaging and gene editing to identify novel components of the Bb and discover their function.Hepatocellular carcinoma (HCC) is the second most lethal type of cancer in the world and lacks effective targeted therapies, in part, due to its genetic heterogeneity. Alexandra Indeglia (matriculated 2019) B.S., 2018 (Chemistry), University of Virginia Thesis Lab: Unknown. Aaron Gitler, PhD (Stanford) Professor, Genetics; Member, Bio-X; Member, Stanford Neurosciences Institute Stanford University. It shares structural similarities with amyloid plaques that cause degenerative disease. Thus, I am interested in studying the role of these hnRNPs in the post-transcriptional regulation of HbF expression.The Balbiani body (Bb) is a transient aggregate found within the oocytes of many species, conserved form insects to humans. However, it is not known exactly how p53 mediates its pleiotropic effects. The project teams have 12 months to complete the work proposed in their Proof-of-Concept Plans.St.
Research has emphasized TDP-43’s role as an RNA binding protein and despite in vitro characterization of TDP-43’s ability to bind DNA, a genome-wide DNA binding map has yet to be defined. Department: Genetics.
I hypothesize that these factors are required for BAT to increase blood flow and oxygen consumption following cold exposure. Access all our content for $20/month.Please complete the consent form before proceeding.In 1998, Murphy became an Assistant Professor at Fox Chase Cancer Center, where she was promoted to Associate Professor in 2003, and Full Professor in 2011. PROGRAM TALKS.
.Sometimes an idea alone is not enough.
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